![]() ![]() Josef Salvat - "Changes - Without You" ( reputainbow)ġ9. Alice Merton - "Blindside" ( Who The Hell Is Leo?✔)ġ8. Lucius - "Second Nature" ( Lordef†ones)ġ6. Acceptance - "At the Edge of the Earth" ( Blurry)ġ4. Maren Morris - "Nervous" ( Az Paynter)ġ2. HAAi/Jon Hopkins - "Baby, We're Ascending" ( Trilogy)ġ0. The War On Drugs - "Change" ( American Idiot)ĩ. Maggie Rogers - "Want Want" ( fearlessarrow)Ħ. The Knocks/Dragonette - "Slow Song" ( walt91)ĥ. Arcade Fire - "The Lightning I, II" ( Pale Shelter)ģ. Pale tags (every group from the tag list thread - this is the only time I'll tag everyone, but if you want to be tagged in other reminders just ask):ġ. Main tags (anyone who was tagged for/sent for recent tournaments): Don't have a meltdown over someone not liking your song(s).Ĩ) I usually don't have to exclude specific songs, but with the re-recordings of Taylor's albums coming over the next year or two, I need to clarify that the only tracks from each album that can be sent are previously unreleased songs in Red's case, that means all of the (From The Vault) tracks, aside from All Too Well (10 Minute Version), since it's an extended version/remix of an old track, rather than an original track in its own right.ĩ) Have fun! There might seem to be a lot of rules to follow, but the most important thing to remember is to not take this too seriously, and discover some great (and less-than-great) music. Do NOT post them in this thread.ħ) Some songs aren't going to do as well that's just fact. If you have any questions about specific songs, please PM me and I'll tell you whether they're eligible.ĥ) When submitting, please mention the artist, any featured artists and the song title (for example, Megan Thee Stallion/Dua Lipa - "Sweetest Pie").Ħ) Again, PM me ( samosaurus1) your songs. Now for some general rules that bear repeating each time these tournaments happen because some people never learn:ġ) There's no limit on the number of participants.Ģ) During the ranking portion, you rank each song from #1 to #, with #1 being your favourite.ģ) Do not use songs that have previously been submitted a complete list will be included in the spoilers at the bottom of the post below this, so please check them before sending anything.Ĥ) I already mentioned eligibility guidelines, but songs are preferred to have been released in the last year, and from the artist's most recent era. If more than those initial songs are needed, I'll PM you, and you'll need to reply ASAP to ensure you have four songs when the tournament starts.Ĥ) As with previous years, DO NOT tell people what your songs are this prevents tanking due to personal biases against certain people. If you absolutely can't get your songs in by then, I'll need to know when you can before the deadline (keep in mind that you don't have to send songs to join in when ranking them).ģ) When you send your songs to me, place your songs in order from your favourite to least favourite, as each person will only have four songs in the tournament, with the songs outside your top 4 being alternates if someone else has the same song as you. Ensure you do this by the 17th June 2022, as there's a lot to get through in this tournament. However, it's generally preferred that the songs are from the artist's most recent era if they weren't released in the last year or so, and most songs released prior to 2021 won't be counted.Ģ) When you have your songs, please send them to me ( samosaurus1) in a PM, not in this thread. This is the second STM we’ve done in the rankdown format (and the seventh rankdown overall), but since some of you will be joining us for the first time, here are the instructions: ( if you're not totally familiar with the format, please read through all of the instructions before sending)ġ) Pick at least 4 songs (but ideally 8) these must be songs you've been enjoying between March and now, but they don't have to have been released in that time period. Once each seed has finished, the top songs will be used in a final rankdown to determine the winner of Summertime Madness 2022! Once the songs have all been revealed, each seed (list of songs) will be put up for ranking by anyone who wants to participate (you can still send a list, even if you didn't submit any songs - the more the merrier!). In STM, each person sends a list of songs they've recently been enjoying, and people will be chosen in a random order to have their top 4 songs picked for the tournament (this prevents people who submit early from having an advantage over those who barely make the deadline). It's time for the return of Summertime Madness! With the approval of, I'll be hosting Summertime Madness this year. (can **everyone** please read this all the way through, especially if you haven't participated in one of these tournaments before) *copies the last tournament’s opening post nearly word-for-word*
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![]() If she has earned a blank slate it is absolutely not because she happens to be bisexual. it takes a lot of strength to come out, especially in a country where nobody wants to hear about it. Mini Portable Pocket Digital LCD AM FM Radio Battery Powered Receiver Speaker 10.79 Was: 10.86 Free shipping Sunflash RD-33 AM/FM 9-Band Mini Radio +Built-In Speaker 11.90 Free shipping HRD-787 Aircraft Radio Mini Aviation Radio Pocket FM AM Air Multiband Radio 54.15 Was: 57. Som Hein () is the stage name of Som Hyein (), born in November 27, 1996. She is currently a model and a Solo Artist who debuted May 23, 2019. According to a more recent poll, conducted in 2017 by Gallup Korea, 90% of South Koreans said they supported equal employment opportunities for LGBT people.īut i believe she is worthy of compassion and support. Som Hein () is a former participant in the survival show IDOL SCHOOL but left in episode 2. They are against things like marriage due to the conservatism, but if you poll LGBT issues it's usually extremely highly supported.Ī 2014 poll found that 85% of South Koreans believed gay people should be protected from discrimination. abused people often become abusersĬonservative yes, anti-lgbt no. She had to leave in the first episode due to health issues, but still maintains a solid online fanbase from the show. Som Hye In was a contestant on the 2017 reality show Idol School, in which 41 singers competed to form a 9-member K-pop girl group. She's a queer woman in a largely anti-lgbt country who probably had to consume a very hateful mindset towards an identity she was coming into, and people manifest their trauma in different ways. A post shared by Somhein (somgodld) on at 1:33pm PDT. You don't get let off or treated any differently for that lol. 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ConclusionĪngry Birds Transformers MOD APK is a great game that can be enjoyed by everyone. ![]() Sunny Hostin Fiercely Defends Kamala Harris Against Alyssa Farah Griffin's Criticism on 'The View' ![]() Hilary Duff Reveals Which Song She'll Be Singing in 'How I Met Your Father' Season 2 'How I Met Your Father': 7 Secrets We Learned from the Season 2 Set Visit 'How I Met Your Father' Flashing Back to 'Lizzie McGuire' Is My 'Multiverse of Madness'Ĭall Leighton Meester's 'How I Met Your Father' Guest Role What It Was: Iconic Stream It Or Skip It: ‘True Spirit’ on Netflix, A Movie Based On The True Story of a Teen's Global Sailing Voyage Stream It Or Skip It: ‘Paws of Fury: The Legend of Hank’ on Prime Video, the Animated Kid-Friendly Version of 'Blazing Saddles' You Didn't Know You Didn't Need ![]() Stream It Or Skip It: ‘Lyle Lyle Crocodile’ on Netflix, an Extremely Silly Musical About a Singing Reptile ‘Hallelujah: Leonard Cohen, a Journey, a Song’ Charts Complicated Route From Creation to Mass Acceptanceĭisney100 Funko Pops Are Here, And They're Adorable 'The Weeknd: Live At Sofi Stadium' Finds The Singer Alone At Center Stage Stream It Or Skip It: 'Daisy Jones & The Six on Prime Video, About The Popular Explosion and Personal Implosion Of A Fictional '70s Rock Band 'Bon Jovi: Live In New York' Sees Band At The Peak Of Their Powers Stream It Or Skip It: 'MH370: The Plane That Disappeared' On Netflix, A Docuseries That Posits Theories On The Malaysia Airlines Flight That Vanished In 2014 'The View' Responds to Will Smith Being "Upset" Over Chris Rock Netflix Special: "He Wasn't the One That Got Slapped" Stream It Or Skip It: ‘Jackass Forever’ on Prime Video, One More Genital-Smashing Go-Round for Johnny Knoxville and His Moron Buddies Stream It Or Skip It: 'Sin Eater' on Hulu, A Jaw-Dropping Exposé of a Major Hollywood Power Player 'Everything Everywhere All At Once' Streaming Info: How To Watch The Oscar-Winning Movie Teary-Eyed Brendan Fraser's Oscar Speech Brings the House Down with Best Actor Win, Nautical Puns LeAnn Rimes Says Her 'Coyote Ugly' Appearance Was an "Introduction" To Her Sexuality Stream It Or Skip It: '80 for Brady' on VOD, A Ladies-Bonding Football Comedy That Fumbles the Ballĭavid Strathairn's Unforgettable Performance In This PBS Film Will Ensure That You 'Remember This' Stream It Or Skip It: 'Chang Can Dunk' on Disney+, a Thoughtful Dramedy About a Classic Tryhard Teen 'Only Murders in the Building’ Season 3 Welcomes Meryl Streep With Hilarious Oscars Teaser Trailer Stream It Or Skip It: 'Have a Nice Day!' on Netflix, a Mexican Dramedy That Delivers on the Promise in the Title Stream It Or Skip It: 'Love at First Kiss' on Netflix, a Spanish Rom-Com About a Man Gifted with 'Romantic Clairvoyance' Netflix Denied Nancy Meyers's $150 Million Rom-Com Budget Request: Report Julia Roberts Allegedly Cost Universal Studios $6 Million After “Disaster” Chemistry Reads for ‘Shakespeare in Love’ Stream It or Skip It: 'Game of Love' on Hallmark, Where Kimberley Sustad and Brooks Darnell Roll the Dice on Romance Released on September 7, 2004, Burnout 3: Takedown is the first Burnout title to be published under the EA banner and the first to receive a T rating from the ESRB. Previous entries were published by Acclaim. Initially available for the PlayStation 2 and Xbox, the game was also released in downloadable form as an Xbox Original on the Xbox 360 in early 2008. Takedown is similar in structure to its predecessor, Burnout 2: Point of Impact. #Burnout 3 takedown ps2 trailer plus#īut the game does have several new features that make it more than the "racing game plus big crashes" formula used in the past. Deathmatch, capture-the-flag and gate racing action 36 wild. New features include Impact Time, which allows players to slow time after a crash in order to direct their mangled frame of a car around the road and, ideally, hit other cars for an Aftertouch Takedown. PART DEMOLITION DERBY, PART WHACKED-OUT CARTOON COME TO LIFE. Drone Takedowns Ultimate Drone Crashes and Takedowns (Part 2) TNT Channel. ![]() This adds a new layer to the game, slowing down the normally intensely high-speed feel in order to get some post-crash satisfaction. Burnout 3 : Takedown (PlayStation 2) - La course aux Takedowns. Players take on multiple event types over the course of the game, including Race, Road Rage, and Crash Mode. ![]() Race is fairly straightforward-first one to the finish line wins. Possessed by a spirit in a dying cornfield, a twelve-year-old girl in Nebraska recruits the other children in her small town to go on a bloody rampage and kill all the adults. Road Rage sets a target number of "takedowns" for the player to reach. #Burnout 3 takedown ps2 trailer drivers#Ĭrash mode pins drivers not against other cars, but rather, against set patterns of parked cars and traffic, making it feel almost like a high-speed puzzle that's solved when you find the precise spot to cause the biggest crash.īurnout 3: Takedown featured online support, allowing up to six players to compete in race events and up to eight in a Crash event. As part of Microsoft's shutdown of Xbox Live for original Xbox games, on April 15th 2010 EA turned off the servers for Xbox and PS2.īurnout 3: Takedown features 18 tracks on three continents USA, Europe and Far East ( Asia). It's also possible to play each track in the opposite direction, doubling the number of tracks to 36. USAĪll Burnout games have provided some sort of status page as to how much of the game has been completed. ![]() Road Rage - 06.00\ Road Rage is when you get as many takedowns as possible in about 3 minutes. This includes a percentage of the over all game you have done. Burnout 3 Takedown (USA) FIXED (XBOX Classic)Games with fix for hang on loading already appliedJust copy the game to the HDDFix by user. You can race on 3 contients, and 40 tracks. To get 100% the player must get all 173 gold medals in World tour (races and crash junctions), all signature takedowns, all crash headlines, and all four Burnout trophies. #Burnout 3 takedown ps2 trailer drivers#. While she felt confident she was in good hands, she admits she felt “so isolated” during her chemotherapy treatment. Her treatment team, including her surgeon, oncologist and plastic surgeon, were all UQ alumni. She also had a full hysterectomy and salpingo-oophorectomy (removal of the ovaries and fallopian tubes). She had 15 rounds of chemotherapy, 25 doses of radiotherapy, and will take an oestrogen-restricting drug for 10 years. ![]() “Skipping unnecessary chemotherapy would have a huge impact on a woman’s quality of life and recovery, while undergoing other treatments like surgery or hormone therapy.”īy the time Bogi's invasive lobular breast cancer was discovered, it had already spread to her lymph nodes. “If a woman who is newly diagnosed and making critical decisions about treatment has a ‘low-risk signature’ and would likely not benefit from chemotherapy, it means she can choose not to have it,” Dr McCart Reed explains. Dr Amy McCart Reed, from Professor Lakhani’s molecular breast pathology team, is an expert in genetics who has helped develop a diagnostic test that in the future could determine if a patient with invasive lobular breast cancer – the second most common type of breast cancer – requires chemotherapy. Personalised models of care is a global movement in cancer science. The new guidelines will help pathologists identify which patients have more aggressive forms of breast cancer, which could see them receive more targeted treatment. Thanks to the work of his team and other researchers around the world, new pathology guidelines on how breast tumours are classified have been included in the World Health Organization’s iconic Blue Book, regarded as the gold standard for diagnosing tumours. We dedicate a game on their calendar where they can honor their loved ones affected by breast cancer, supply the students with pink shoelaces, and they show their spirit by wearing their "Pink" socks, t shirts, and more in school and at the game.The Asia-Pacific Metaplastic Breast Cancer Consortium, formed by researchers at UQ's Centre for Clinical Research (UQCCR), is led by Professor Sunil Lakhani. The Students Unite for HER program is an outreach opportunity where our young community can give back to others in need. What a sense of community we are a part of here in West Chester and we are honored to bring our Students Unite for HER program to Chester County, where we can give directly back to the community that supports us so greatly." Their enthusiasm and positive energy was contagious and everyone around them felt it! We all had the privilege of witnessing students becoming young philanthropist in their community, setting such a positive example of how one can get involved at any age and give so freely of themselves to help others in need. Unite President Sue Weldon went on to say, "As a breast cancer survivor, I was personally so inspired by these boys and girls. As young citizens in our community, your students are setting such a wonderful example of how one can get involved, give back and pass it on.” “Our community is truly amazing in every sense of the word,” she said, “and witnessing these young boys and girls reach out the way they did last week was greater than mere words can express. ![]() Unite for HER President and Founder Sue Weldon, a breast cancer survivor herself, was overwhelmed by the students’ demonstration of support. Such sharing also helps to ease any emotional or financial burden they may experience. Any school raising more than $1000 with Unite for HER fundraising efforts receives a $300 grant back to the school for one of their students with a mother affected by breast cancer. More than $3,300 was raised - a “Students Unite for HER” record – and both Fugett and Peirce Middle Schools thereby qualified to receive a grant for use within each school’s community. Student Unite efforts that included football, soccer, field hockey contests created an incredible outpouring of support and good will. United States Lompoc CA, Vandenberg AFB ( Blue and red printed) cachet on Geosat-1 launch cover Spacenet-1/2/3/3R type (Spacenet-1/2 became ChinaSat-5/5R) ASC-1/2 type ( ASC-2 became Spacenet-4)Ĭopyright © 2018-2022, Colorado State University. Spacenet (on other than Spacenet launch covers)įrench Guiana Kourou (Association Philatélique du CNES) back of Telecom-1B and GStar-1 launch cover, also front "Spacenet I", "Spacenet II", "Spacenet III" and "Spacenet IV" (on back) United States Patrick AFB, FL (Grey-brown printed) cachet on cover Spacenet-4 (ASC-2) launch SEP Section Philatélie) cachet on cover Spacenet-3R launchįrench Guiana Kourou (Lollini) cachet on cover Spacenet-3R launch (not " GStar-3R" as in text)įrench Guiana Kourou (Association philatélique du CNES) cachet on cover, also back Spacenet-3R launch (also "Spacenet I", "Spacenet II" and "Spacenet III", on back)įrance Paris (Lollini) cachet on cover Spacenet-3R launch SEP Section Philatélie) cachet on cover Spacenet-3 launch įrench Guiana Kourou (Association Philatélique du CNES) cachet on cover, also back Spacenet-3 launch įrench Guiana Kourou (CPK) cachet on cover Spacenet-3 launch įrench Guiana Kourou (CPK) cachet (different) on cover Spacenet-3 launch įrench Guiana Kourou (CPK black and magenta printed and black rubber-stamp) cachet on cover Spacenet-3R launchįrench Guiana Kourou (CPK blue and pink and black printed) cachet on cover Spacenet-3R launchįrench Guiana Kourou (CPK black and magenta rubber-stamp) cachet on cover Spacenet-3R launchįrench Guiana Kourou (CPK black and green rubber-stamp) cachet on cover Spacenet-3R launchįrench Guiana Kourou (CPK black and blue rubber-stamp) cachet on cover Spacenet-3R launchįrench Guiana Kourou (CPK photo) cachet on card Spacenet-3R launchįrench Guiana Kourou (CPK red and black rubber-stamp) cachet on card Spacenet-3R launchįrench Guiana Kourou (CPK) cachet on cover Spacenet-3R launchįrench Guiana Kourou (MBB-ERNO Philatelie) cachet on cover Spacenet-3R launchįrench Guiana Kourou (C.E. : Spacenet-3 (and Eutelsat-1-F3) įrench Guiana Kourou (Green and black printed) cachet on cover Spacenet-3 launch įrench Guiana Kourou (Lollini) cachet on cover Spacenet-3 launch įrench Guiana Kourou (Conseil de l'Europe) cachet on cover Spacenet-3 launch įrench Guiana Kourou (Black rubber-stamp) cachet on cover Spacenet-3 launch įrench Guiana Kourou (Black and red rubber-stamp) cachet on cover Spacenet-3 launch įrench Guiana Kourou (CPK) cachet on postcard Spacenet-3 launch įrench Guiana Kourou (C.E. SEP Section Philatélie) cachet on cover, also back Spacenet-2 launch (but Arabsat-1 depicted)įrench Guiana Kourou (CPK?) cachet on card Spacenet-2 launchįrench Guiana Kourou (Carsten Fuchs/Ken Havekotte) cachet on cover Spacenet-2 launch ![]() ![]() SEP Section Philatélie) cachet on cover Spacenet-1 launchįrance Paris (Lollini) cachet on cover Spacenet-1 launchįrench Guiana Kourou (Club Philatélique ESA/Lollini) cachet on cover Spacenet-2 launchįrench Guiana Kourou (C.E. In (upper-left) margin of imperforate SS1 (i886) 1998 "Spacenet" (but Telecom-1 depicted)īelow is a list of Spacenet-series satellite launch covers (including anniversary-of-launch covers, and launch-related event covers).Ĭountry Cancel Date Cancel Location Type of Item Notes on Contentįrench Guiana Kourou (Lollini) cachet on cover Spacenet-1 launchįrench Guiana Kourou (Lollini) cachet (different) on cover Spacenet-1 launchįrench Guiana Kourou (C.E. In (upper-left) margin of imperforate SS1 (i1031) 1987 Spacenet Spacenet Spacenet Spacenet (on other than Spacenet launch covers)īelow is a list of Spacenet-series satellite postal items (stamps, souvenir sheets, aerogrammes, postal cards, etc.).Ĭountry Catalog Number Type of Item Year of Issue Notes on Content (stamps, souvenir sheets, aerogrammes, postal cards, etc.) (including anniversary-of-launch covers, and launch-related event covers) If readers know of additional information or images, please contact the authors using the e-mail addresses at the bottom of this page. ![]() Catalog numbers, years of issue, and notes on the satellites featured are given when available. This page contains philatelic information on Spacenet (SPACE NETwork) series satellites. Rather, turnover becomes a problem when organizations struggle to retain their very best talent and this negatively impacts the bottom line. It’s important to note that not all voluntary turnover is bad - like the loss of the employee with a negative track record for productivity or the team member who clashes with the workplace culture. If, for example, an organization has 30,000 employees and an average voluntary turnover rate of 13 percent, the potential cost to the organization is a staggering $427.7 million in one year. ![]() It’s also a very costly problem.Īccording to Bersin by Deloitte research, the average voluntary turnover rate is 13 percent. PricewaterhouseCooper’s 2017 annual survey found 77 percent of CEOs are concerned that key skills shortages could impair their company’s growth. The Cost of Employee TurnoverĮmployee turnover is the single most prevalent HR metric. Data-driven organizations use workforce analytics to identify the employees who are most likely to resign and more importantly, why, so the right levers can be pulled to stem the tide of employees rushing for the exits. Now is the time to find out which of your best performers may be calling it quits in the new year. ![]() Data from Glassdoor specifically calls out January as the month when more employees are likely to leave. This is the time of year when employers need to be proactive with their employee retention strategies. ![]() The other main cast from the series includes Riya Sen, Freddy Daruwala and Tanuj Virwani. Shiraz Ahmed is the writer of the show, with Jatin Wagle writing it.īollywood actor Arbaaz Khan marks his digital debut with this series. Poison is a Hindi action crime thriller bold web series. Releasing in 2019, the sexy web series has ten episodes in total. ![]() “This story of love, friendship and politics of college life is unlike anything you have seen before.” “Sex, Drugs & Theatre is a masterpiece and a definite must-watch for those who seek novel themes in the Indian web space. Saraah T writing in her blog for prettylilthingss1, compliments the series, saying: They reluctantly unite together to put on a play and feature in a prominent competition. The web show is about the lives of six students from the art department who are into sex and drugs. The director Sujay also has a pivotal role in the series. The series stars Shalva Kinjawadikar, Mitali Mayekar, Nayannah Mukey, Aadish Vaidya, Suyash Zunzurke, Abhishek Deshmukh, Pravin Trade and Sunil. Most of the cast are familiar as they come from the Marathi film industry. It is ZEE5 original release. Marking his digital debut is filmmaker and director of this series, Sujay Dahake. ![]() Sex, Drugs & Theatre is a Marathi bold web series. The final season consisting of four episodes went on air from April 5, 2019. Season two with six parts released on September 18, 2018. Season one comprising of ten episodes came out on July 16, 2018. Karenjit Kaur: The Untold Story of Sunny Leone has a total of twenty episodes over three seasons. But I did not know it would be so difficult. “And after talking to everyone I was satisfied that if it would be my story then I can do it. “I think the curiosity is in my fans, who want to know about me, so when you are telling your story, then that should be true, whatever things have happened with you. ![]() There is not one thing, the whole story is important. “I told different incidents, they have beautifully been weaved in the story. Additionally, it was very challenging to tell her story: Sunny Leone told Zee News she was a little hesitant at the start. Let's find out what boundaries she is willing to cross to see her husband successful.Bijay Jasjit Anand (Jaspal Singh Vohra) Grusha Kapoor (Balwant Kaur Vohra) and Marc Buckner (Daniel Webber: Karenjit’s husband) also have important characters.Ĭape Town (South Africa) and Mumbai (India) are the two primary locations of the series. There are scenes of sex and nudity in the series, which is available in various languages. When his wife Priya comes to know about it from her mutual friend Nidhi, she makes a plan to get the Contract approved. Due to this all his dreams and family plans get shattered. Story: The story revolves around a guy named Rajiv, who gets disappointed when his Contract doesn't get approved in spite of his hard work. This web series is directed by Harsh Mishra and produced by Rakshit Sikand and it cast includes Simran Kaur, Sumit Singh, Hitesh Sharma and others. Contract has been topping the charts ever since its first day air on Hotshots.Ī unique format and storytelling have helped Contract become one of the popular web series on Hotshots. Contract is one of the most popular web series released on Hotshots. ![]() ![]() Read moreīackgroundHLX02 is an approved biosimilar of trastuzumab.Objective Thus, the major benefit of the luminal B subclassification may be in selecting patients who are most apt to benefit from taxanecontaining chemotherapy, which would then render their prognosis similar to that of the luminal A group. Examining Figure 4 in the article, one has the impressionthatuseofdocetaxel,doxorubicin,andcyclophosphamide rendered the disease-free survival of the luminal B group without HER2-positive patients almost equivalent to that of the luminal A group. The major difference between the luminal A and B groups without HER2 considered would be the Ki67-1 index, which was high in the majority of patients in the luminal B group and low in all patients in the luminal A group. Because we routinely treat all HER2-positive patients with Herceptin (trastuzumab Genentech,SouthSanFrancisco,CA)andchemotherapy,itwouldbeofgreatinteresttoseedisease-freeandoverallsurvival fortheluminalBgroupwithoutincludingtheHER2-positivepatients. epidermal growth factor receptor 2 (HER2) ‐positive groups-22% of the patients were HER2 positive. However, in the luminal B group-in which, compared with the luminal A group, survival was midway between the triple-negative and human. TO THE EDITOR: The article by Hugh et al 1 presents a useful classification of node-positive breast cancer to indicate survival and best use of chemotherapy with docetaxel, doxorubicin, and cyclophosphamide versus fluorouracil, doxorubicin, and cyclophosphamide. These data suggest that biosimilar trastuzumab MYL-1401O has similar effectiveness and cardiac safety to RTZ in patients with HER2-positive EBC or MBC. ![]() The overall response rate, disease control rate, and cardiac safety profiles did not show significant differences in efficacy outcomes between the 2 groups. Median PFS was also similar in MBC, at 23.0 months (95% CI, 9.8-26.1) in patients receiving MYL-1401O and 23.0 months (95% CI, 19.9-26.0) in patients receiving RTZ (P =. Progression-free survival (PFS) at 12, 24, and 36 months was similar in the 2 cohorts of the EBC-adjuvant group: 96.3%, 84.7%, and 71.5%, respectively, in patients receiving MYL-1401O, and 100%, 88.5%, and 64.8% in patients receiving RTZ (P =. The rate of achieving pathologic complete response in patients receiving neoadjuvant chemotherapy was similar between those receiving MYL-1401O and RTZ (62.7% and 55.9%, respectively P =. We identified patients with HER2-positive early-stage breast cancer (EBC) (n = 159) who had received neoadjuvant chemotherapy with RTZ or MYL-1401O ± pertuzumab (n = 92) or adjuvant chemotherapy with RTZ or MYL-1401O plus taxane (n = 67) between January 2018 and June 2021, as well as patients with MBC (n = 53) who had received palliative first-line treatment with RTZ or MYL-1401O and docetaxel ± pertuzumab or second-line treatment with RTZ or MYL-1401O and taxane between January 2018 and June 2021. We retrospectively investigated medical records. Here, we present the first real-world comparison of MYL-1401O vs RTZ as single/dual HER2-targeted therapy for the neoadjuvant, adjuvant, and palliative treatment of HER2-positive breast cancer in the first and second lines. The trastuzumab biosimilar MYL-1401O has demonstrated equivalent efficacy and comparable safety to reference trastuzumab (RTZ) in clinical trials of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) as HER2 monotherapy. |